Cancer Cell Metabolism: Warburg and Beyond
نویسندگان
چکیده
منابع مشابه
Cancer Cell Metabolism: Warburg and Beyond
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.
متن کاملCancer metabolism: the Warburg effect today.
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with co...
متن کاملTargeting Cancer Metabolism - Revisiting the Warburg Effects
After more than half of century since the Warburg effect was described, this atypical metabolism has been standing true for almost every type of cancer, exhibiting higher glycolysis and lactate metabolism and defective mitochondrial ATP production. This phenomenon had attracted many scientists to the problem of elucidating the mechanism of, and reason for, this effect. Several models based on o...
متن کاملThe Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells
Abstract Current definitions of cancer are best realized as a list of traits or hallmarks, such as tissue invasion, metastasis, cell-autonomous growth, and resistance to apoptosis. A recent update included deregulated cellular energetics as an emerging hallmark. However, debate about tumor cell metabolism occupied center stage in the pre-oncogene era. Over the last 15 years, direct links of onc...
متن کاملMetabolic changes in cancer: beyond the Warburg effect.
Altered metabolism is one of the hallmarks of cancer cells. The best-known metabolic abnormality in cancer cells is the Warburg effect, which demonstrates an increased glycolysis even in the presence of oxygen. However, tumor-related metabolic abnormalities are not limited to altered balance between glucose fermentation and oxidative phosphorylation. Key tumor genes such as p53 and c-myc are fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.08.021